Revista multidisciplinaria
investigación Contemporánea ISSN-e: 2960-8015Vol. 3 -No. 207 - 2025
Regenerative medicine as a therapeutic alternative for chronic diseases
and serious injuries: Advances, challenges and clinical applications
DOI: https://doi.org/10.58995/redlic.rmic.v3.n2.a115
552-575
Regenerative medicine as a
therapeutic alternative for chronic
diseases and serious injuries:
Advances, challenges and clinical
applications
La medicina regenerativa como alternativa
terapéutica para enfermedades crónicas y lesiones
graves: Avances, desafíos y aplicaciones clínicas
Cueva Criollo Emily Juliet 1
1 Universidad Técnica Particular de Loja; emilyjulietc@gmail.com. Loja, Ecuador.
How to cite:
Cueva Criollo, E. J. (2025). Regenerative medicine as a therapeutic alternative for chronic diseases and
serious injuries: Advances, challenges, and clinical applications. Multidisciplinary Journal of Contemporary
Research, 3(2), 552–575. https://doi.org/10.58995/redlic.rmic.v3.n2.a115
Article Information
Received: 25-02-2025
Accepted: 22-05-2025
Published: 01-07-2025
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The research was conducted using the authors’
own resources.
Conicts of Interest
No conicts of interest are declared.
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Revista multidisciplinaria
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DOI: https://doi.org/10.58995/redlic.rmic.v3.n2.a90
Leucemia de células dendríticas plasmocitoides
- estudio y diagnóstico de un caso 49 -49
Copyright (c) 2025 Faicán Rocano Pedro Fernando, Dután Pérez Ibelice Salomé,
González González Camila Raquel, Matute Aguiar Joselyn Nayeli, Rodríguez Ver-
dugo Alejandra Valentina.
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Review article. Revista Multidisciplinaria Investigación Contemporánea.
Vol. 3 - No. 2, pp. 552 - 575. July-December, 2025. e-ISSN: 2960-8015
DOI: https://doi.org/10.58995/redlic.rmic.v3.n2.a115
Revista multidisciplinaria
Investigación Contemporánea 07 - 2025 Vol. 3 - No. 2 ISSN-e: 2960-8015
DOI: https://doi.org/10.58995/redlic.rmic.v3.n2.a90
Leucemia de células dendríticas plasmocitoides
- estudio y diagnóstico de un caso 32 -49
Artículo Caso clínico. Revista multidisciplinaria investigación Contemporánea.
Vol. 3 - No. 2, pp. 32 - 49. julio-diciembre, 2025. e-ISSN: 2960-8015
Leucemia de células dendríticas
plasmocitoides - estudio y diagnóstico
de un caso
Leucemia de células dendríticas plasmocitoides - estudio y
diagnóstico de un caso
Información del artículo:
Recibido: 05-12-2024
Aceptado: 21-02-2025
Publicado: 01-07-2025
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1 Docente Investigador; pedro.faican@ucacue.edu.ec. Azogues, Ecuador.
2 Estudiante; ibelice.dutan.44@est.ucacue.edu.ec. Azogues, Ecuador.
3 Estudiante; camila.gonzalez.66@est.ucacue.edu.ec. Azogues, Ecuador.
4 Estudiante; joselyn.matute.44@est.ucacue.edu.ec. Azogues, Ecuador.
5 Estudiante; alejandra.rodriguez.60@est.ucacue.edu.ec. Azogues, Ecuador.
Faicán Rocano Pedro Fernando 1, Dután Pérez Ibelice Salomé 2, González González Camila
Raquel 3, Matute Aguiar Joselyn Nayeli 4, Rodríguez Verdugo Alejandra Valentina 5
DOI: https://doi.org/10.58995/redlic.rmic.v3.n2.a90
Cómo citar:
Faican Rocano, P. . F., Dután Pérez, I. S. ., González González, C. R. ., Rodríguez Verdugo, A. V. ., & Matute Aguiar, J.
N. . (2025). Leucemia de células dendríticas plasmocitoides - estudio y diagnóstico de un caso.
Revista Multidisci-
plinaria Investigación Contemporánea
, 3(2), 32-49. https://doi.org/10.58995/redlic.rmic.v3.n2.a90
Revista multidisciplinaria
investigación Contemporánea ISSN-e: 2960-8015Vol. 3 -No. 207 - 2025
Regenerative medicine as a therapeutic alternative for chronic diseases
and serious injuries: Advances, challenges and clinical applications
DOI: https://doi.org/10.58995/redlic.rmic.v3.n2.a115
553-575
Summary
In recent years, regenerative medicine has experienced remarkable progress
and the emergence of new applications, as well as signicant challenges. This
review article aims to analyze the advances, clinical applications, and challenges
in regenerative medicine to drive further development and research in this eld.
The research adopted a qualitative approach and followed the systematic review
protocol based on the PRISMA 2020 guidelines. Key advances include 3D bioprinting
and cellular reprogramming, which have enabled the creation of functional
tissues and organs in the laboratory, as well as the development of therapies to
regenerate musculoskeletal tissue and vital organs from stem cells. Although many
experimental studies on cell regeneration face challenges such as immunological
compatibility and validation in aspects of safety and efcacy, these studies show
great potential for more effective and less invasive treatments. According to the
Regenerative Medicine 2030 Report, conducted in 2023, the regenerative medicine
therapy market was valued at USD 30.43 billion worldwide; and an annual growth
of 16.79% is expected from 2024 to 2030. In addition, a deeper understanding of
the cellular and molecular mechanisms involved in organ and tissue regeneration
has been achieved. The results demonstrate signicant advances in regenerative
medicine through the use of stem cells, platelet-rich plasma, organoids, and 3D
printing, highlighting their application in the regeneration of bone, cartilage,
neuronal, skin, and ocular tissue. Ethical and technical regulatory challenges
are identied, such as the need for standardization, regulatory approval, and the
development of safe and effective protocols for their clinical implementation.
While regenerative medicine therapies are emerging as promising therapeutic
alternatives for chronic diseases and serious injuries, continued interdisciplinary
research is essential to advance their development and consolidate a future in
which these conditions can be treated more efciently and with less invasive
methods, thus transforming medical practice.
Keywords: 3D bioprinting, stem cells, regenerative medicine, cell therapy,
cell reprogramming.
Revista multidisciplinaria
investigación Contemporánea ISSN-e: 2960-8015Vol. 3 -No. 207 - 2025
Regenerative medicine as a therapeutic alternative for chronic diseases
and serious injuries: Advances, challenges and clinical applications
DOI: https://doi.org/10.58995/redlic.rmic.v3.n2.a115
554-575
Abstract
In recent years, regenerative medicine has seen remarkable progress and the
emergence of new applications, as well as signicant challenges. This review article
aims to analyze the advances, clinical applications, and challenges in regenerative
medicine to drive further development and research in this eld. The research
adopted a qualitative approach and followed the systematic review protocol
based on the PRISMA 2020 guidelines. Key advances include 3D bioprinting and
cellular reprogramming, which have enabled the creation of functional tissues
and organs in the laboratory, as well as the development of therapies to regenerate
musculoskeletal tissues and vital organs from stem cells. Although many
experimental studies on cell regeneration face challenges such as immunological
compatibility and validation in terms of safety and efcacy, these studies show
great potential for more effective and less invasive treatments. According to the
Regenerative Medicine 2030 Report, conducted worldwide in 2023, the regenerative
medicine therapy market was valued at USD 30.43 billion; and an annual growth
of 16.79% is expected from 2024 to 2030. In addition, a deeper understanding of
the cellular and molecular mechanisms involved in organ and tissue regeneration
has been achieved. The results demonstrate signicant advances in regenerative
medicine through the use of stem cells, platelet-rich plasma, organoids, and 3D
printing, highlighting their application in the regeneration of bone, cartilage,
neuronal, skin, and ocular tissue. Ethical and technical regulatory challenges
are identied, such as the need for standardization, regulatory approval, and the
development of safe and effective protocols for their clinical implementation.
While regenerative medicine therapies are emerging as promising therapeutic
alternatives for chronic diseases and serious injuries, continued interdisciplinary
research is essential to advance their development and consolidate a future in
which these conditions can be treated more efciently and with less invasive
methods, thus transforming medical practice
Key words: 3D bioprinting, stem cells, regenerative medicine, cell therapy,
cell reprogramming.
Revista multidisciplinaria
investigación Contemporánea ISSN-e: 2960-8015Vol. 3 -No. 207 - 2025
Regenerative medicine as a therapeutic alternative for chronic diseases
and serious injuries: Advances, challenges and clinical applications
DOI: https://doi.org/10.58995/redlic.rmic.v3.n2.a115
555-575
1. Introduction
Regenerative medicine has emerged as a promising therapeutic
alternative within the eld of medical sciences, as a response to the
constant search to improve the quality of life of people suffering from
chronic diseases and serious injuries (1). This innovative eld of medicine
not only offers hope, but also tangible solutions for patients with
degenerative diseases, organ transplants and trauma who previously
seemed incurable or were affected by limited treatments (2).
In fact, the rapid advances in regenerative medicine have completely
transformed the approach to various conditions ranging from spinal
cord injuries to diseases such as Parkinson’s, Alzheimer’s and Diabetes
Mellitus. These conditions continue to be investigated for treatment
through stem cell tissue regeneration (2). This branch of medical science
has sparked renewed interest among the scientic community, healthcare
professionals and, above all, among patients and their families.
Regenerative medicine is dened as an emerging multidisciplinary
eld that seeks to repair or replace injured tissues or organs through
tissue engineering (3). It is divided into three main approaches: stem cells,
growth factors, and extracellular matrix or scaffolding (3). Each approach
has the therapeutic potential to regenerate tissues to restore their normal
function, rather than simply alleviate the symptoms of diseases.
Regenerative medicine offers a number of signicant benets for
patients, healthcare professionals, and society at large. These include the
possibility of personalized treatment, reduced long-term dependence on
medications, improved quality of life, and the potential reduction in costs
associated with long-term medical care (4) .
There are several regenerative medicine techniques, such as cell
therapy, tissue engineering, and genomic medicine, that have become
major advances in the eld of medicine. Researchers in regenerative
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and serious injuries: Advances, challenges and clinical applications
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medicine are exploring new ways to harness the body’s regenerative
potential to treat a wide range of conditions.
of pathologies. This regeneration-focused approach represents a
paradigm shift in the treatment of chronic diseases and serious injuries
(5).
The increasing incidence of chronic diseases and serious injuries in
contemporary society demonstrates an urgent need for new therapeutic
strategies. In this context, regenerative medicine, by focusing on tissue
repair and regeneration, offers more lasting and less invasive solutions
than conventional treatments. This represents a genuine expectation for
patients facing debilitating or potentially fatal medical conditions (6).
Thus, the main objective of this study is to analyze the latest
advances, challenges, and clinical applications of regenerative medicine
in the treatment of chronic diseases and serious injuries. Through a
comprehensive review of the scientic and clinical literature, we aim
to identify current trends, clinical and ethical implications, and future
opportunities in this promising and dynamic eld.
Methodology
The current research was carried out from a qualitative approach,
following the systematic review protocol based on the PRISMA 2020
guidelines Preferred Reporting Items for Systematic Reviews and Meta-
Analyses), which led the search, selection and analysis of relevant studies
(Appendix A). The research variables were advances, challenges and
clinical applications in regenerative medicine.
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and serious injuries: Advances, challenges and clinical applications
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Search Strategy:
A systematic search was conducted in databases such as Scopus,
Google Scholar, PubMed, Uptodate, Dialnet Plus, Science Direct. The
use of keywords and Boolean operators allowed the publications to be
specied, as follows: (“Medicine” AND “Regenerative”; “Chronic Diseases”
AND NOT “Acute Diseases”; “Stem Cells” OR “Tissue Regeneration” OR
“Cell Therapy” OR “Tissue Engineering”).
To narrow down the search results, the following lters were
applied: time limit (2017-2024), subject area (Medicine; biochemistry,
genetics and molecular biology, Engineering), document types (articles,
reviews, editorials, conference papers, books), keywords (regenerative
medicine, stem cells, tissue regeneration, cell therapy), language (Spanish
and English), and documents that are available online and do not require
payment for access were included.
Eligibility Criteria:
The selected publications meet the following inclusion criteria: (1)
Study types such as: scientic articles, review articles, clinical trials, books,
theses, observational studies, meta-analyses; (2) Interventions related to
regenerative medicine treatment, such as cell therapy, gene therapy, tissue
engineering, 3D bioprinting, etc. (3) Studies published from January 2017
to February 2024; (4) Studies published in English and Spanish.
The exclusion criteria applied in the literature search are listed
below: (1) Duplicate studies or those with a high risk of methodological
or quality bias; (2) Studies evaluating regenerative therapies for acute
or supercial diseases that are not considered within the scope of the
topic;(3) Publications outside the time range of January 2017 to February
2024; (4) Studies published in languages other than English and Spanish.
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Study Selection and Data Extraction:
The researcher was responsible for ltering out publications
that did not meet the inclusion criteria. Studies were selected based on
keywords and a reading of their abstracts, methodology, and conclusions.
A narrative synthesis of the ndings of the included studies was also
conducted, highlighting the advances, challenges, and clinical applications
of regenerative medicine in the treatment of chronic diseases and serious
injuries.
Figure 1. PRISMA diagram
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Table 1. Results
Qualication Authors Year Type of
Study Aim Results
INTESTINAL
ORGANOIDS:
Present and future
of biomedical
research
Díaz, C. 2023 Review
article
To provide
an updated,
literature-based
overview of the
applications
of intestinal
organoids in
biomedicine
and their future
potential.
Intestinal organoids have proven useful
in regenerative and precision medicine,
as they have demonstrated the ability
to model intestinal physiology and
diseases, as well as epithelial damage
caused by various agents. These models
have allowed for in-depth studies of the
molecular biology of various pathologies
and the search for specic treatments. (7).
New approaches
to developing
safer strategies
in regenerative
medicine
Alkhraisat,
M.,
Troy, M.,
Zalduendo,
M.,
Anitua, E.
2019 Scientic
article
Explore the
advances,
challenges,
and clinical
implications of
regenerative
medicine,
emphasizing the
use of autologous
biological
materials such
as PRGF-Endoret
for personalized
tissue repair and
regeneration.
PRGF-Endoret is a system that offers
autologous biomaterial enriched with
proteins and growth factors, capable of
recreating three-dimensional matrices,
providing a physical and bioactive
environment for the regeneration and
replication process. PRGF-Endoret
has been shown to enhance the
hemostatic effect, reduce the intensity
of inammation, and accelerate the
proliferative and remodeling phases of
bone tissue.
The results also demonstrate that PRGF-
Endoret is an alternative for the isolation,
culture and ex vivo conservation of stem
cells from different origins, without the
risk of pathogen transmission or immune
rejection, maintaining their phenotype
and multilineage differentiation potential
(4) .
Regenerative
medicine:
fundamentals and
applications
Isaza, C.,
Henao, J.,
Aranzazu, J.
2018 Review
Article
To systematically
review and
organize
the latest
information on
the principles
and applications
of regenerative
medicine.
Stem cells are special cells that can
transform into other types of cells to aid
tissue regeneration. Research indicates
that when combined with demineralized
bone and platelet-rich plasma, fracture
healing is accelerated. They are also
effective in the treatment of osteoarthritis,
as they promote cartilage regeneration
(4).
In the eld of eye diseases, the rst
commercial drug based on stem cells has
already been approved for the treatment
of corneal burns. Furthermore, it has been
proven that the intradermal application
of stem cells can prevent the formation
of excessive surgical scars, preserving the
normal structure and function of the skin
(4) .
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and serious injuries: Advances, challenges and clinical applications
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Ethics in the eld
of Regenerative
Medicine Research
Quesada, L.,
Barrios, C.,
Díaz, Z.
2021 Review
Article
To examine
the ethical
aspects involved
in research,
fostering critical
reection,
both cognitive
and ethical,
on scientic
development
in the eld of
regenerative
medicine.
Regenerative medicine carries great
ethical importance both in assessing
the treatment of various diseases and
in making responsible decisions. This
includes respecting the limits of the
patient’s informed consent.
Maintaining an appropriate ethical stance
in regenerative medicine allows us to
measure the impact of treatment with a
responsible and humane attitude.
Ethics in
regenerative
medicine and
platelet-rich plasma
treatment
Quesada,
L., León, C.,
Quintana, E.
2021 Review
article
Analyzing
regenerative
medicine and
platelet-rich
plasma treatment
from an ethical
perspective
The ethical perspective linked to the
use of platelet-rich plasma within
regenerative medicine facilitated the
analysis of scientic and technological
advances, ensuring comprehensive,
timely and structured medical care,
supported by trained professionals and at
an affordable and sustainable cost. (2) .
Background of the
application of cell
therapy as a health
technology in
medical and dental
diseases.
Julia, R.,
Aurora, N.,
León, K.,
Riccis, S.,
Yolaidays, I.,
Naughty, N.
2023 Review
article
To characterize
the background
of the use of
cell therapy as
a healthcare
technology in
the treatment
of medical and
dental diseases.
The historical study of the application of
cell therapy in the treatment of medical
and dental diseases has provided insight
into its origin, evolution, and current
status. In this context, cell therapy
represents an innovative and promising
option compared to conventional
treatments for tissue regeneration (1) .
Neurodegenerative
diseases and
Cellular
reprogramming:
therapeutic
potential and
promise of
rejuvenation
Lehmann, M.,
Mallat, M.,
Chiavellini,
P.,
Brown, O.,
Goya, R.
2019 Book
chapter
To describe
emerging
evidence
indicating
that aging is
a reversible
epigenetic
process, along
with novel
reprogramming
methods that
would avoid
the risks
associated with
conventional
techniques
requiring the
generation
of induced
pluripotent stem
cells (iPSCs).
Research into the production of neural
cells, both in vitro and, to a lesser extent,
in vivo, is constantly advancing. This line
of research seeks to develop safe and
effective protocols for obtaining patient-
derived cells that can be applied in the
treatment of neurological diseases such
as Parkinson’s, Alzheimer’s, and other
similar neurological pathologies. (8).
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The business
of regenerative
medicine and stem
cells: confusion with
legal implications
Cuende, N.,
Álvarez-
Márquez, A.,
Díaz-Aunión,
C.,
Castro, P.,
Huet, J.,
Pérez-
Villares, J.
2021 Review
article
To outline the
fundamental
requirements
for the use of
autologous
biological
products, with
the aim of
offering practical
guidance for both
the professionals
who prescribe
them and those
who supervise
the centers
where they are
administered.
The use of autologous biological
products such as platelet-rich plasma
(PRP) requires compliance with specic
regulations, including advanced therapy
manufacturing labeling, manufacturing in
authorized laboratories, and compliance
with regulations from the Spanish Agency
for Medicines and Medical Devices
(AEMPS). For experimental therapies
involving cells and tissues, ethical
approval and regional authorization are
required. Furthermore, advanced therapy
medicinal products must comply with
transplant regulations regarding aspects
such as donation, donor evaluation,
and traceability. The Spanish National
Transplant Organization (Spanish
National Transplant Organization) has
also issued regulations regarding medical
devices used to obtain autologous cells
and the classication of the resulting
product as an advanced therapy
medicinal product.
In the case of cell and tissue transplants
that are considered experimental
therapies, the sponsor, in addition to
submitting the study for evaluation to the
corresponding research ethics committee,
must request authorization from the
competent authority of his autonomous
community (the Autonomous Transplant
Coordination) ( 9)
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III Congress on
Tissue Engineering
and Regenerative
Medicine
Weinstein-
Oppenheimer,
C.,
Acevedo, C.
2023 Scientic article
To promote the
exchange of ideas and
cooperation within the
scientic community
in areas such as
tissue engineering,
biomaterials,
regenerative medicine,
and global scientic and
technological advances
that will inuence
future therapies, with
the goal of contributing
to the well-being and
quality of life of society.
Signicant progress has been made in
research on Additive Biomanufacturing
and its challenges in tissue replacement
within Regenerative Medicine. The
application of two biomanufacturing
methodologies enabled the
implementation of a high-resolution 3D
bioprinting system capable of utilizing
multiple materials and cells. Furthermore,
the fabrication and validation of cellular
tissues in animal models was achieved, as
well as the development of a novel system
for arthroscopic remarking of cartilage
lesions. (7) .
Regenerative
medicine, its
applications and
foundations
Pacios, J.,
Barrosos, M. 2023 Review article
To systematically
compile and organize
the most current
information on the
principles and potential
uses of regenerative
medicine.
The safety of regenerative medicine is
supported by various investigations whose
results are optimistic about the benets of
this new therapeutic strategy, and it is also
assured that new treatment regimens based
on regenerative medicine will continue to
emerge in the coming years (10) .
Stem cells as
an alternative
to transvenous
pacemakers
Martínez de
Hoyo, K.,
Ortega Enciso,
A.,
Mendoza
Beltrán, F.,
Reynolds
Pombo, J.
2020 Review article
To analyze the current
development of
biological pacemakers
and explore future
prospects for creating
cardiac tissue with
pacemaker function
using advanced genetic
technologies and tissue
engineering.
Biological pacemakers, although in
a preclinical stage of development,
constitute an alternative to electronic
devices for patients with selected
cardiac diseases in the future. The main
challenges faced are the difculty in
ensuring long-term engraftment and
the potential risk of proarrhythmias (11)
con avances en el dise˜no del cable, el
tama˜no del generador, la longevidad de
la batería y los algoritmos de software
que se han traducido en dispositivos más
peque˜nos con funcionalidad mejorada.
En la actualidad existen muchos sistemas
implantables de cardioestimulación
capaces de reemplazar la función de los
marcapasos siológicos (seno y nódulos
aurículo-ventriculares.
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How will skin
care change
with research
advances?
Rodriguez, P. 2018 Editorial
To analyze the efcacy
of biomaterials such
as umbilical cord
brin scaffolds in
the regeneration of
deep wounds and
their contribution to
regenerative medicine.
The use of biomaterials through tissue
engineering techniques allows for new
treatment approaches for traditional
skin wounds. A successful example
is the application of brin scaffolds
obtained from the umbilical cord for the
treatment of deep wounds, which achieved
homogeneous, scar-free regenerated skin.
This allows us to conclude that research
advances in regenerative medicine will
serve as a support to current treatments
to contribute to and improve tissue
reconstruction (12) .
Inuence of
advances in tissue
engineering and
regenerative
medicine on the
progress and
evolution of health
Madan Patel,
G.,
Borah, N.,
Kumar, G.
2023 Review article
Examine how
regenerative medicine,
tissue engineering,
and 3D bioprinting
work together, while
emphasizing advances
in bioprinting
technology for
transplantable organs
and tissues.
Tissue engineering and regenerative
medicine work together to create new
tissues and organs to offer an alternative
to patients with deteriorating organs
or debilitating diseases. Studies show
that 3D bioprinting has the potential to
manufacture or mimic patient-specic
natural tissues from scaffolds and stem
cells, where the healing and regeneration
process is carefully controlled through
the release of growth factors. However,
improvements are needed to bring this
technology to clinical application, but it
remains an innovative technology for the
future of medicine (5) .
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Advances in the
development
of organoids as
study models
in regenerative
medicine
Aguilar, P. 2018 Thesis
To conduct a literature
review to analyze
current knowledge
on the development
of organoids as study
models in the eld of
regenerative medicine,
with a particular focus
on intestinal organoids.
The study of organoids, mini organs grown
in the laboratory, is booming due to their
potential in regenerative medicine. The
goal is to improve their development
so that they better mimic real organs
and optimize their transplantation to
replace damaged organs. This opens
the door to personalized treatment
options for intestinal diseases and
personalized medicine (13) se pueden
crear unidades funcionales de diferentes
órganos, denominados organoides, que
se autoorganizan in vitro formando una
estructura 3D, capaces de reproducir tanto
la función como la estructura del órgano
equivalente in vivo. Aunque tienen muchas
más aplicaciones, son muy importantes
en medicina regenerativa ya que pueden
ser útiles para el tratamiento de un gran
número de enfermedades donde el órgano
no funciona como es debido, ya sea por un
defecto genético, por un traumatismo o por
otras causas. En este estudio se recogen los
últimos avances en el desarrollo, así como
en las diferentes formas de maduración de
los organoides para su posterior trasplante
en el huésped, centrándonos en los
organoides intestinales y en las diferentes
enfermedades que afectan a este órgano.
(13.
3D printers, their
innovation in the
eld of medicine
Alejandro, L.,
Rodríguez, D. 2020 Review article
Analyze the evolution
of 3D printing, from
its beginnings to the
moment it became
established as a method
of innovation in
medicine.
3D printing in medicine is a great
innovation that guarantees more
personalized and affordable care, which
brings great benets and good results to
patients (7) .
Regenerative
medicine for
the treatment of
neurodegenerative
diseases
López-léón, M.,
Lehmann, M.,
Goya, R.
2017 Book section
Explore the potential of
cellular reprogramming
as a therapeutic strategy
to restore impaired
brain function, focusing
on its applications
in the treatment of
neurodegenerative
diseases such as
Alzheimer’s and
Parkinson’s.
Mature cellular reprogramming technology
will provide, in the not too distant future,
effective means to functionally restore the
aged brain. Two approaches have been
identied: lineage reprogramming and
direct reprogramming using pluripotency
factors, both aimed at investigating
therapeutic alternatives for degenerative
diseases such as Alzheimer’s and
Parkinson’s (6) .
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Comparative
analysis of
bioprinters
using additive
manufacturing
technologies with
biomaterials,
with the aim of
evaluating their
efciency in
generating organs
and tissues for the
biomedical eld.
Viera Valencia,
L.,
García Giraldo,
D.
2019 Thesis
To conduct a
comparative study of
bioprinters that use
additive processes with
biomaterials, with the
aim of determining
their effectiveness in
creating organs and
tissues.
Additive process technology with bioinks
and biomaterials offers the possibility of
manufacturing personalized models and
medical supplies adapted to the specic
needs of each patient (14) .
Narrative review
on the use of
platelet-rich
plasma as an
autologous
therapy in
regenerative
medicine.
Aguilar, R.,
Cáceres, A. 2020 Review article
To present the
theoretical foundations
that support the
potential use of platelet-
rich plasma (PRP) and
its growth factors in
regenerative therapies
through autologous
biostimulation,
especially in diseases
that still lack a specic
treatment.
Platelet-rich plasma (PRP) is an
autologous treatment used to enhance cell
regeneration and tissue healing. Although
there is no standardized procedure for
its use, PRP has been shown to improve
vascular permeability, cell regeneration,
tissue healing, and immune response.
Further studies are needed to better
understand its mechanism of action, but
PRP could be useful in degenerative and
viral diseases such as COVID-19. In this
context, it could be used as a complement
during asymptomatic phases, in order to
modulate the immune system, promote
the regeneration of damaged organs and
tissues, and control the progression of
multisystem biodegradation (15).
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Standardization of
a 3D bioprinting
protocol for
creating scaffolds
with potential
applications in
tissue engineering.
Castellanos
Garzón, J.,
Correa
Quiceno, M.,
Peñaranda
Armbrecht, J.,
Holguín Ruiz,
J.,
King
Piedrahíta, A.
2023 Scientic report
To standardize a 3D
bioprinting protocol for
creating scaffolds with
potential applications
in tissue engineering.
Materials such as
polycaprolactone
(PCL), polylactic acid
(PLA) lament, exible
lament, and various
bioinks were used.
Key parameters such as bed temperature,
PLA lament temperature and extrusion
speed were adjusted in the REGEMAT 3D
bioprinter, achieving the manufacture of
three scaffolds with different geometries,
potentially useful in areas such as
otorhinolaryngology and orthopedics (16)
la medicina está siendo complementada y
fortalecida con los avances en desarrollo
de biomateriales y técnicas como la
bioimpresión 3D para la producción de
andamios y estructuras orientadas a la
reparación, la regeneración o reemplazo
de tejidos dañados, afectados por alguna
patología o trauma, como también
en la prueba de fármacos y la entrega
controlada de sustancias utilizadas en
el tratamiento de enfermedades, dando
paso a la investigación en ingeniería de
tejidos, que se dene como la ciencia del
diseño y fabricación de nuevos tejidos,
siendo un campo multidisciplinar que
requiere de los aportes de la biología
para el cultivo celular, de la ingeniería de
materiales y la química para el desarrollo
de estructuras 3D denominadas andamios
y de profesionales de la salud para su
implementación en medicina regenerativa.
En este sentido, la Unidad Central del
Valle del Cauca incentivando la vocación
cientíca de los estudiantes del programa
de ingeniería biomédica, adquirió el
equipo de bioimpresión 3D REGEMAT3D
R4L que cuenta con una tecnología que ha
sido optimizada para imprimir distintos
tipos de tejidos como cartílago, piel, hueso
y para trabajar con distintos tipos de
biomateriales, colágenos, nanocelulosas,
termoplásticos. Para potencializar el uso
del equipo, la Universidad Central del Valle
(UCEVA.
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What are the
advances,
challenges,
and clinical
applications of
regenerative
medicine as
a therapeutic
alternative for
chronic diseases
and serious
injuries?
Hosseini S,
Taghiyar L,
Safari F,
Baghaban
Eslaminejad M.
2018 Scientic article
To explore the
opportunities for using
mesenchymal stem cells
(MSCs), their desirable
therapeutic properties
in regenerative
medicine, and their
potential implications
for clinical practice.
Regenerative medicine and tissue
engineering represent the most promising
therapeutic biological strategies
utilizing mesenchymal stem cells
(MSCs). Mesenchymal stem cells have a
high capacity for self-renewal through
immunomodulatory properties, making
them eligible for clinical applications (21).
Applications
of stem cells in
regenerative
medicine and
disease treatment.
Mahla R. 2016 Review article
It examines a framework
for the most recent
advances in embryonic
stem cell (ESC)
transplantation and
tissue engineering
technologies, and the
tissue-in-tissue role
of hematopoietic stem
cells (ESCs). It also
discusses stem cells as
tools for regenerative
use in wildlife
conservation.
Stem cells have diverse applications in
tissue regeneration and disease treatments.
Embryonic stem cells (ESCs) come from
the inner mass of the blastocyst and are
used in the treatment of neurodegenerative
diseases such as spinal cord injuries and
macular degeneration.
Mesenchymal stem cells (MSCs) are
present in bone marrow, adipose tissue,
and the umbilical cord and are effective for
peritoneal brosis and tissue regeneration.
Likewise, these umbilical cord-derived
cells are used to treat type 1 and 2 diabetes,
improving beta cell function.
Induced pluripotent stem cells (iPSCs)
are adult cells reprogrammed to enhance
their pluripotent characteristics. These
have applications in the regeneration of
damaged tissues and the restoration of
neuronal functions. The aforementioned
therapies are under development and
require research to standardize their
use and monitor results on a large scale,
since they can be very useful in organ
transplantation and the treatment of
immunological disorders (17) . Research
is focused on improving the efcacy and
tolerance of stem cell transplants (17).
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Discussion
In the last two decades, regenerative medicine has made great strides
in diverse elds such as molecular biology, biomedical engineering,
biochemistry, physics, and ethics. One of these advances is 3D bioprinting,
which would allow the generation of functional organs and tissues in the
laboratory. 3D bioprinting consists of the technique of manufacturing
three-dimensional tissues and organs, using living cells as raw material
(18). This advance includes the design and manufacture of biological
structures with biocompatible materials, based on scaffolds and stem cells,
which are controlled by a computer to create complex three-dimensional
models (6). This process resembles conventional 3D printing, replacing
ink with biomaterials and cells.
After bioprinting, the tissue or organ is subjected to an incubation
bioprocess to promote cell maturation, the use of growth factors to induce
cell differentiation, as well as the implementation of perfusion techniques
to promote the formation of blood vessels in organs. However, tissue
vascularization and the development of new biomaterials continues to
be a challenge for 3D bioprinting (14). In this regard, Castellanos-Garzón
(16), in his studies, has included a bioprinting technological material,
manufacturing three structures with different geometries designed
for possible applications in otorhinolaryngology and orthopedics.
Likewise, Aguilar (16) in his research work points out that this method of
regenerative medicine is very promising to improve organ transplantation
and personalized medicine.
Another signicant advance found in the review articles regarding
regenerative medicine is cellular reprogramming, which consists of the
development of therapies based on induced stem cells for the regeneration
of damaged tissues and damaged or diseased organs (8). Stem cells are
the so-called stem cells that have the characteristic of self-renewing and
dividing to produce new or specialized stem cells. In addition, they can
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release molecules that help repair damage caused by injury or disease
and aging (10).
Stem cells serve as treatments in musculoskeletal tissues,
regeneration of the heart, liver and central nervous system. Hence (8)
Lehmann et al., (2018) He points out that stem cell treatments are becoming
an alternative treatment for diseases such as Parkinson’s and Alzheimer’s,
as well as therapeutic applications for injuries and grafts.
Thus, the main applications of regenerative medicine are found
in tissue reproduction, to treat traumatic, degenerative or congenital
injuries of the musculoskeletal system such as bone fractures, cartilage
and tendon injuries, and diseases such as osteoarthritis (18). By using
stem cells, biomaterials and growth factors, therapies can be developed
to promote the regeneration of musculoskeletal tissues, restoring their
structure and function effectively.
Another key application of regenerative medicine is the regeneration
of vital organs and tissues. This area of research seeks to address
chronic and degenerative diseases, as well as the shortage of organs for
transplants. These regenerative therapies offer new hope for patients
with terminal illnesses, providing the possibility of more effective and less
invasive treatments in the future. Aguilar (15) in his experimental study
demonstrated that the transplantation of epithelial organoids developed
from stem cells is effective for the treatment of diseases that negatively
affect the intestinal epithelium, as he experimented with mice suffering
from acute colitis, achieving successful treatment. This application is quite
prospective for the regenerative treatment of several human diseases.
Despite its promising applications, regenerative medicine faces
several challenges that limit its full application. These include the need
to overcome immunological barriers and ensure the compatibility of
regenerated tissues with the recipient’s immune system, especially in the
case of tissue and organ transplants (18). Furthermore, the identication
of suitable biomaterials and the optimization of cell culture techniques
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are essential to ensure the vascularization and functionality of tissues
biofabricated through 3D printing (14).
Other challenges include generating adequate amounts of stem
cells in vitro, while avoiding exposing the sample to hazards such as
contamination or malignant transformation (19). Finally, according to
Quesada Leyva et al. (20), the ethical, regulatory, risk and safety aspects
of regenerative treatments for human application need to be considered.
Ongoing research and interdisciplinary collaboration are essential to
address these challenges and fully harness the potential of regenerative
medicine for the benet of human health.
Conclusions
Recent advances in regenerative medicine, such as 3D bioprinting,
have shown great potential for the manufacture of anatomically functional
tissues and organs in laboratories. This technique allows for the creation
of complex biological structures using living cells and biomaterials, which
could revolutionize medical elds such as otorhinolaryngology and
orthopedics.
Cell reprogramming, another important advance in regenerative
medicine, offers new hope for the treatment of a variety of diseases, as well
as injuries. This strategy, which involves the development of induced stem
cell-based therapies, could be key in the treatment of diverse conditions,
from musculoskeletal injuries to neurodegenerative disorders such as
Parkinson’s and Alzheimer’s.
The primary applications of regenerative medicine focus on the
regeneration of musculoskeletal tissues and vital organs, such as the
heart, liver, and central nervous system. These advances represent a
paradigm shift in the treatment of chronic and degenerative diseases,
offering new hope for patients with serious medical conditions. However,
despite its promising applications, regenerative medicine faces signicant
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challenges that must be addressed. These include the need to ensure the
immunological compatibility of regenerated tissues, as well as ethical and
willingness-based donations, regulations, and safety considerations that
require rigorous attention.
The topic of regenerative medicine is exciting, as it opens the door
to a future where chronic diseases and serious injuries could be treated
more effectively and less invasively. However, achieving this goal requires
continued research and closer interdisciplinary collaboration. More in-
depth experimental research is needed to better understand the cellular
and molecular mechanisms involved in tissue and organ regeneration,
as well as to develop new technologies and therapeutic approaches.
Furthermore, more clinical studies and trials are needed to evaluate
the safety and efcacy of regenerative therapies in humans. The ethical
considerations involved in this medicine must also be taken into account,
which could be the subject of further research.
In conclusion, regenerative medicine represents an evolution in
the approach to chronic diseases and serious injuries, offering innovative
therapeutic alternatives based on the use of stem cells, biomaterials,
and emerging technologies such as 3D bioprinting and organoids.
While scientic advances have demonstrated high potential for tissue
regeneration and personalized treatments, ethical, technical, and
regulatory challenges remain that require attention to ensure safety,
efcacy, and accessibility. The consolidation of this eld will depend on
strengthening interdisciplinary research, standardizing procedures, and
establishing clear regulations that allow for its proper integration into
clinical practice.
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